Article
RCS1, a substrate of APC/C, controls the metaphase to anaphase transition.
Proceedings of the National Academy of Sciences of the United States of America - 9 Sept 2008
Zhao Wei-Meng, Coppinger Judith A, Seki Akiko, Cheng Xiao-Li, Yates John R, Fang Guowei
Abstract excerpt
The anaphase-promoting complex/cyclosome (APC/C) controls the onset of anaphase by targeting securin for destruction. We report here the identification and characterization of a substrate of APC/C, RCS1, as a mitotic regulator that controls the metaphase-to-anaphase transition. We showed that the levels of RCS1 fluctuate in the cell cycle, peaking in mitosis and dropping drastically as cells exit into G(1)....
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