Article
Arguments for the sake of endophenotypes: examining common misconceptions about the use of endophenotypes in psychiatric genetics.
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics - 1 Mar 2014
Glahn David C, Knowles Emma E M, McKay D Reese, Sprooten Emma, Raventós Henriette, Blangero John, Gottesman Irving I, Almasy Laura
Abstract excerpt
Endophenotypes are measurable biomarkers that are correlated with an illness, at least in part, because of shared underlying genetic influences. Endophenotypes may improve our power to detect genes influencing risk of illness by being genetically simpler, closer to the level of gene action, and with larger genetic effect sizes or by providing added statistical power through their ability to quantitatively rank...
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