Article
Structural cerebral variations as useful endophenotypes in schizophrenia: do they help construct "extended endophenotypes"?
Schizophrenia bulletin - 1 Jul 2008
Prasad Konasale M, Keshavan Matcheri S
Abstract excerpt
Endophenotypes represent intermediate phenotypes on the putative causal pathway from the genotype to the phenotype. They offer a potentially valuable strategy to examine the molecular etiopathology of complex behavioral phenotypes such as schizophrenia. Neurocognitive and neurophysiological impairments that suggest functional impairments associated with schizophrenia have been proposed as endophenotypes. However,...
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