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Article

Quantitative endophenotypes as an alternative approach to understanding genetic risk in neurodegenerative diseases.

Neurobiology of disease - 1 Apr 2021

Farias Fabiana H G, Benitez Bruno A, Cruchaga Carlos

Abstract excerpt

Endophenotypes, as measurable intermediate features of human diseases, reflect underlying molecular mechanisms. The use of quantitative endophenotypes in genetic studies has improved our understanding of pathophysiological changes associated with diseases. The main advantage of the quantitative endophenotypes approach to study human diseases over a classic case-control study design is the inferred biological...

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PMID: 33429041
DOI: 10.1016/j.nbd.2020.105247

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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