Article
Endophenotypes in the genetic analyses of mental disorders.
Annual review of clinical psychology - 1 Jan 2006
Cannon Tyrone D, Keller Matthew C
Abstract excerpt
Common mental disorders such as schizophrenia, bipolar disorder, and severe major depression are highly heritable, but differ from single-gene (Mendelian) diseases in that they are the end products of multiple causes. Although this fact may help explain their prevalence from an evolutionary perspective, the complexity of the causes of these disorders makes identification of disease-promoting genes much more...
Topics
- Chromosome Mapping
- Family
- Gene Expression
- Genetic Markers
- Genetic Predisposition to Disease
- Genetic Techniques
- Genetic Variation
- Humans
- Mental Disorders
- Models, Genetic
- Phenotype
- Schizophrenia