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Article

Alterations in corticostriatal synaptic plasticity in mice overexpressing human alpha-synuclein.

Neuroscience - 17 Mar 2009

Watson J B, Hatami A, David H, Masliah E, Roberts K, Evans C E, Levine M S

Abstract excerpt

Most forms of Parkinson's disease (PD) are sporadic in nature, but some have genetic causes as first described for the alpha-synuclein gene. The alpha-synuclein protein also accumulates as insoluble aggregates in Lewy bodies in sporadic PD as well as in most inherited forms of PD. The focus of the present study is the modulation of synaptic plasticity in the corticostriatal pathway of transgenic (Tg) mice that...

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Identifiers

PMID: 19361478
DOI: 10.1016/j.neuroscience.2009.01.021
PMCID: PMC2670358

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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