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Article

Impaired synaptic plasticity in mice carrying the Huntington's disease mutation.

Human molecular genetics - 1 May 1999

Usdin M T, Shelbourne P F, Myers R M, Madison D V

Abstract excerpt

Cognitive impairment is an early symptom of Huntington's disease (HD). Mice engineered to carry the HD mutation in the endogenous huntingtin gene showed a significant reduction in long-term potentiation (LTP), a measure of synaptic plasticity often thought to be involved in memory. However, LTP could be induced in mutant slices by an 'enhanced' tetanic stimulus, implying that the LTP-producing mechanism is intact...

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Identifiers

PMID: 10196373
DOI: 10.1093/hmg/8.5.839

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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