Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Alterations in synaptic transmission and long-term potentiation in hippocampal slices from young and aged PDAPP mice.

Brain research - 4 Sept 1999

Larson J, Lynch G, Games D, Seubert P

Abstract excerpt

Synaptic transmission and plasticity were studied in the CA1 field of hippocampal slices from young and aged transgenic mice over-expressing a mutant form of the human amyloid precursor protein (PDAPP mice). The transgenic mice at 4-5 months of age, prior to the formation of amyloid-beta peptide deposits in these animals, differed from non-transgenic control mice in three respects: (1) paired-pulse facilitation...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyloid beta-Protein Precursor
Share to Electric Stimulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Excitatory Postsynaptic Potentials

Share to Hippocampus

Share to In Vitro Techniques

Share to Long-Term Potentiation

Share to Plaque, Amyloid

Share to Synaptic Transmission

Source

Identifiers

PMID: 10517949
DOI: 10.1016/s0006-8993(99)01698-4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Alterations in synaptic transmission and long-term potentiation in hippocampal slices from young and aged PDAPP mice.PMID 10517949Read ↗

Differences in Synaptic Dysfunction Between rTg4510 and APP/PS1 Mouse Models of Alzheimer's Disease.Semantic proximity Read ↗

Age-related synaptic dysfunction in Tg2576 mice starts as a failure in early long-term potentiation which develops into a full abolishment of late long-term potentiation.Semantic proximity Read ↗

Altered short-term hippocampal synaptic plasticity in mutant alpha-synuclein transgenic mice.Semantic proximity Read ↗

Synaptic plasticity in the hippocampus of a APP/PS1 mouse model of Alzheimer's disease is impaired in old but not young mice.Semantic proximity Read ↗

Age-related impairment of synaptic transmission but normal long-term potentiation in transgenic mice that overexpress the human APP695SWE mutant form of amyloid precursor protein.Semantic proximity Read ↗

In vivo synaptic transmission in young and aged amyloid precursor protein transgenic mice.Semantic proximity Read ↗

Synaptic dysfunction in hippocampus of transgenic mouse models of Alzheimer's disease: a multi-electrode array study.Semantic proximity Read ↗

Alterations in corticostriatal synaptic plasticity in mice overexpressing human alpha-synuclein.Semantic proximity Read ↗

Long-term potentiation is increased in the CA1 area of the hippocampus of APP(swe/ind) CRND8 mice.Semantic proximity Read ↗

An in vitro and in vivo study of early deficits in associative learning in transgenic mice that over-express a mutant form of human APP associated with Alzheimer's disease.Semantic proximity Read ↗

Plaque-independent disruption of neural circuits in Alzheimer's disease mouse models.Semantic proximity Read ↗

Hippocampal synaptic plasticity in Alzheimer’s disease: what have we learned so far from transgenic models?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.