Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Aging and alpha-synuclein affect synaptic plasticity in the dentate gyrus.

Journal of neural transmission (Vienna, Austria : 1996) - 1 Jan 2009

Gureviciene Irina, Gurevicius Kestutis, Tanila Heikki

Abstract excerpt

Although intracellular accumulation of alpha-synuclein (alpha-syn) is a characteristic pathological change in Parkinson's disease, Lewy body dementia and Alzheimer's disease, the normal function of this presynaptic protein is still unknown. To assess the contribution of alpha-syn to synaptic plas...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biophysics
Share to Dentate Gyrus
Share to Electric Stimulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Escape Reaction

Share to Excitatory Postsynaptic Potentials

Share to Locomotion

Share to Neuronal Plasticity

Share to Reaction Time

Source

Identifiers

PMID: 19002552
DOI: 10.1007/s00702-008-0149-x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-19002552-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Aging and alpha-synuclein affect synaptic plasticity in the dentate gyrus.PMID 19002552Read ↗

Altered short-term hippocampal synaptic plasticity in mutant alpha-synuclein transgenic mice.Semantic proximity Read ↗

Role of alpha-synuclein in synaptic glutamate release.Semantic proximity Read ↗

Alterations in corticostriatal synaptic plasticity in mice overexpressing human alpha-synuclein.Semantic proximity Read ↗

αβγ-Synuclein triple knockout mice reveal age-dependent neuronal dysfunction.Semantic proximity Read ↗

Behavioral characterization of A53T mice reveals early and late stage deficits related to Parkinson's disease.Semantic proximity Read ↗

Age-related synaptic dysfunction in Tg2576 mice starts as a failure in early long-term potentiation which develops into a full abolishment of late long-term potentiation.Semantic proximity Read ↗

Hippocampal network hyperexcitability in young transgenic mice expressing human mutant alpha-synuclein.Semantic proximity Read ↗

Differences in Synaptic Dysfunction Between rTg4510 and APP/PS1 Mouse Models of Alzheimer's Disease.Semantic proximity Read ↗

Forebrain overexpression of alpha-synuclein leads to early postnatal hippocampal neuron loss and synaptic disruption.Semantic proximity Read ↗

Alpha-synuclein: between synaptic function and dysfunction.Semantic proximity Read ↗

Age-related impairment of synaptic transmission but normal long-term potentiation in transgenic mice that overexpress the human APP695SWE mutant form of amyloid precursor protein.Semantic proximity Read ↗

Reduction of synaptojanin 1 ameliorates synaptic and behavioral impairments in a mouse model of Alzheimer's disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.