Article
Association of hOGG1 genotype with life style and oxidative DNA damage among Chinese ethnic populations.
Archives of toxicology - 1 Jul 2009
Ke Yuebin, Zhang Zhunzhen, Jiang Youshen, Zhuang Zhixiong, Li Lu, Lu Wenqing, Wu Tangchun
Abstract excerpt
To assess the natural variation of hOGG1 gene and the gene-environmental interactions, the hOGG1 codon 326 polymorphism and urinary 8-OHdG levels were investigated in large samples (n = 953) of healthy individuals from five Chinese ethnic populations by using PCR-RFLP and HPLC-ECD. Life-style parameters under study were obtained through a questionnaire. The allelic frequencies of the hOGG1 gene in the Chinese...
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