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Two functional variations in 5'-UTR of hoGG1 gene associated with the risk of breast cancer in Chinese.

Breast cancer research and treatment - 1 Jun 2011

Chen Xiaoxiang, Wang Jingmei, Guo Wenwen, Liu Xiufang, Sun Caixia, Cai Zhenming, Fan Yimei, Wang Yaping

Abstract excerpt

8-Hydroxy-2'-deoxyguanine (8-OHdG) is produced by the oxidative stress-induced damage in DNA, which could pair with adenine (A) during DNA replication, leading to G-T transversion mutations. Glycosylase hOGG1 can recognize and excise oxidized guanines from duplex DNA. This work aims to investigate the relationship between the functional variations in 5-untranslated region (5'-UTR) of hOGG1 gene and the risk of...

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PMID: 21153698
DOI: 10.1007/s10549-010-1284-2

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