Polymorphic variation in hOGG1 and risk of cancer: a review of the functional and epidemiologic literature.

doi:10.1002/mc.20067

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Article

Polymorphic variation in hOGG1 and risk of cancer: a review of the functional and epidemiologic literature.

Molecular carcinogenesis - 1 Mar 2005

Weiss J M, Goode E L, Ladiges W C, Ulrich Cornelia M

Abstract excerpt

The gene encoding human 8-oxoguanine glycosylase 1 (hOGG1) is involved in DNA base excision repair. The encoded DNA glycosylase excises 7,8-dihydro-8-oxoguanine (8-OHdG), a highly mutagenic base produced in DNA as a result of exposure to reactive oxygen species (ROS). Polymorphisms in this gene may alter glycosylase function and an individual's ability to repair damaged DNA, possibly resulting in genetic...

Topics

DNA Glycosylases
DNA Repair
Epidemiologic Studies
Genetic Predisposition to Disease
Humans
Neoplasms
Polymorphism, Genetic

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PMID: 15584022
DOI: 10.1002/mc.20067

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