Article
hOGG1 Ser(326)Cys polymorphism and modification by environmental factors of stomach cancer risk in Chinese.
International journal of cancer - 1 Jun 2002
Takezaki Toshiro, Gao Chang-ming, Wu Jian-zhong, Li Zhong-you, Wang Jian-dong, Ding Jian-hua, Liu Yan-ting, Hu Xu, Xu Tian-liang, Tajima Kazuo, Sugimura Haruhiko
Abstract excerpt
Oxidative stress is involved in many types of DNA damage, e.g., resulting in 8-hydroxyguanine adducts. Since a human counterpart exists for the yeast gene OGG1 (hOGG1) encoding an enzyme that repairs 8-hydroxyguanine, its polymorphism, Ser(326)Cys, might have potential as a genetic marker for can...
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