Article
Oxidative DNA damage in peripheral leukocytes and its association with expression and polymorphisms of hOGG1: a study of adolescents in a high risk region for hepatocellular carcinoma in China.
World journal of gastroenterology - 1 Oct 2003
Peng Tao, Shen Han-Ming, Liu Zhi-Ming, Yan Lu-Nan, Peng Min-Hao, Li Le-Qun, Liang Ren-Xiang, Wei Zong-Liang, Halliwell Barry, Ong Choon Nam
Abstract excerpt
AIM: To study the oxidative DNA damage to adolescents of hepatocellular carcinoma (HCC) families in Guangxi Zhuang Autonomous Region, China. METHODS: Peripheral leukocytes' DNA 7, 8-dihydro-8-oxoguanine (8-oxoG) and repair enzyme hOGG1 were quantified by flow-cytometry. hOGG1-Cys326Ser single nucleotide polymorphism (SNP) was distinguished by polymerase chain reaction-single strand conformational polymorphism...
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