Article
hOGG1 Ser326Cys polymorphism and lung cancer susceptibility.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Aug 1999
Sugimura H, Kohno T, Wakai K, Nagura K, Genka K, Igarashi H, Morris B J, Baba S, Ohno Y, Gao C, Li Z, Wang J, Takezaki T, Tajima K, Varga T, Sawaguchi T, Lum J K, Martinson J J, Tsugane S, Iwamasa T, Shinmura K, Yokota J
Abstract excerpt
The human homologue of the yeast OGG1 gene, hOGG1, has been cloned, and its genetic structure has been determined. Several polymorphisms in the hOGG1 gene were detected in the Japanese populations, and among them, the Ser-Cys polymorphism at codon 326 has been shown to have a functional difference in complementation of mutant Escherichia coli that is defective in the repair of 8-hydroxyguanine. Activity in the...
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