Article
hOGG1 Ser326Cys polymorphism, interaction with environmental exposures, and gastric cancer risk in Japanese populations.
Cancer science - 1 Dec 2004
Tsukino Hiromasa, Hanaoka Tomoyuki, Otani Tetsuya, Iwasaki Motoki, Kobayashi Minatsu, Hara Megumi, Natsukawa Syusuke, Shaura Kozo, Koizumi Yoichi, Kasuga Yoshio, Tsugane Shoichiro
Abstract excerpt
Oxidative DNA damage caused by reactive oxygen species (ROS) generated by Helicobacter pylori (H. pylori ) infection or smoking may be a cause of gastric cancer development. 8-Hydroxydeoxyguanine (8-OHdG) formation is one of the most common types of oxidative DNA damage, while human oxoguanine glycosylase 1 (hOGG1) is responsible for repairing 8-OHdG lesions. Among several hOGG1 gene polymorphisms, the Ser-->Cys...
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