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Article

Abnormal development of the neuromuscular junction in Nedd4-deficient mice.

Developmental biology - 1 Jun 2009

Liu Yun, Oppenheim Ronald W, Sugiura Yoshie, Lin Weichun

Abstract excerpt

Nedd4 (neural precursor cell expressed developmentally down-regulated gene 4) is an E3 ubiquitin ligase highly conserved from yeast to humans. The expression of Nedd4 is developmentally down-regulated in the mammalian nervous system, but the role of Nedd4 in mammalian neural development remains poorly understood. Here we show that a null mutation of Nedd4 in mice leads to perinatal lethality: mutant mice were...

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Identifiers

PMID: 19345204
DOI: 10.1016/j.ydbio.2009.03.023
PMCID: PMC2810636

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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