Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Nedd4-2 haploinsufficiency causes hyperactivity and increased sensitivity to inflammatory stimuli

8 Sept 2016

Abstract excerpt

Nedd4-2 (NEDD4L in humans) is a ubiquitin protein ligase best known for its role in regulating ion channel internalization and turnover. Nedd4-2 deletion in mice causes perinatal lethality associated with increased epithelial sodium channel (ENaC) expression in lung and kidney. Abundant data suggest that Nedd4-2 plays a role in neuronal functions and may be linked to epilepsy and dyslexia in humans. We used a...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Biochemical effects in animals
Share to Coenzyme Q10 studies and effects
Share to Genetics and Neurodevelopmental Disorders

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 27604420
DOI: 10.1038/srep32957

Provenance

PubMed metadata and Literature Corpus relationships.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Nedd4-2 haploinsufficiency causes hyperactivity and increased sensitivity to inflammatory stimuliPMID 27604420Read ↗

Epilepsy-associated gene Nedd4-2 mediates neuronal activity and seizure susceptibility through AMPA receptors.Semantic proximity Read ↗

Physiological and pathophysiological homeostasis of astroglial channel proteins by Nedd4-2Semantic proximity Read ↗

NEDD4-2 as a potential candidate susceptibility gene for epileptic photosensitivity.Semantic proximity Read ↗

NEDD4L on human chromosome 18q21 has multiple forms of transcripts and is a homologue of the mouse Nedd4-2 gene.Semantic proximity Read ↗

A novel mouse Nedd4 protein suppresses the activity of the epithelial Na+ channel.Semantic proximity Read ↗

AAV-mediated overexpression of Prdm12 in knee-innervating afferents reduces inflammatory joint pain and neuronal hyperexcitability in miceSemantic proximity Read ↗

Transcription factor mesenchyme homeobox protein 2 (MEOX2) modulates nociceptor functionSemantic proximity Read ↗

Precise genetic mapping and integrative bioinformatics in Diversity Outbred mice reveals Hydin as a novel pain gene.Semantic proximity Read ↗

Hotfoot mouse mutations affect the delta 2 glutamate receptor gene and are allelic to lurcher.Semantic proximity Read ↗

Cnksr2 Loss in Mice Leads to Increased Neural Activity and Behavioral Phenotypes of Epilepsy-Aphasia Syndrome.Semantic proximity Read ↗

Genetic diseases and gene knockouts reveal diverse connexin functions.Semantic proximity Read ↗

NeuroD: the predicted and the surprising.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.