Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Neddylation E1 Obligatory Subunit Nae1 Is Critical to Neuromuscular Junction Development and Maintenance.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 13 Aug 2025

Jing Hongyang, Wu Minyi, Xing Guanglin, Lin Dong, Chen Peng, Li Lei, Yu Zheng, Zhang Hongsheng, Wang Hongsheng, Su Huabo, Xiong Wen-Cheng, Mei Lin

Abstract excerpt

Rapsyn is a scaffold protein that is thought to anchor acetylcholine receptors at the neuromuscular junction (NMJ). We showed that it may be an E3 ligase that regulates NMJ development by neddylation. To obtain genetical evidence, we mutated Nae1 (APP-BP1), an obligatory subunit of the neddylation E1 enzyme specifically in muscle cells. The mutation decreased the stability of acetylcholine receptor (AChR)α,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animals, Newborn
Share to Mice, Inbred C57BL

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mice, Transgenic

Share to Muscle Proteins

Share to Neuromuscular Junction

Share to Receptors, Cholinergic

Share to Ubiquitin-Activating Enzymes

Share to Ubiquitin-Protein Ligases

Source

Open in PubMed Open full text

Identifiers

PMID: 40659529
DOI: 10.1523/JNEUROSCI.0098-25.2025
PMCID: PMC12352533

Genes

APP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Neddylation E1 Obligatory Subunit Nae1 Is Critical to Neuromuscular Junction Development and Maintenance.PMID 40659529Read ↗

Control of rapsyn stability by the CUL-3-containing E3 ligase complex.Semantic proximity Read ↗

A mechanism in agrin signaling revealed by a prevalent Rapsyn mutation in congenital myasthenic syndromeSemantic proximity Read ↗

A Role of Lamin A/C in Preventing Neuromuscular Junction Decline in Mice.Semantic proximity Read ↗

LAP proteins are localized at the post-synaptic membrane of neuromuscular junctions and appear to modulate synaptic morphology and transmission.Semantic proximity Read ↗

Autophagy linked FYVE (Alfy/WDFY3) is required for establishing neuronal connectivity in the mammalian brainSemantic proximity Read ↗

DOCK7 regulates WNT signaling and NMJ clustering in normal and DMD muscleSemantic proximity Read ↗

Ariadne-1: a vital Drosophila gene is required in development and defines a new conserved family of ring-finger proteins.Semantic proximity Read ↗

A splice isoform of DNedd4, DNedd4-long, negatively regulates neuromuscular synaptogenesis and viability in Drosophila.Semantic proximity Read ↗

Genetic diseases and gene knockouts reveal diverse connexin functions.Semantic proximity Read ↗

Innexins: members of an evolutionarily conserved family of gap-junction proteins.Semantic proximity Read ↗

Human homologue of a gene mutated in the slow Wallerian degeneration (C57BL/Wld(s)) mouse.Semantic proximity Read ↗

Abnormal development of the neuromuscular junction in Nedd4-deficient mice.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.