Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Motoneuron Wnts regulate neuromuscular junction development.

eLife - 16 Aug 2018

Shen Chengyong, Li Lei, Zhao Kai, Bai Lei, Wang Ailian, Shu Xiaoqiu, Xiao Yatao, Zhang Jianmin, Zhang Kejing, Hui Tiankun, Chen Wenbing, Zhang Bin, Hsu Wei, Xiong Wen-Cheng, Mei Lin

Abstract excerpt

The neuromuscular junction (NMJ) is a synapse between motoneurons and skeletal muscles to control motor behavior. Unlike extensively investigated postsynaptic differentiation, less is known about mechanisms of presynaptic assembly. Genetic evidence of Wnt in mammalian NMJ development was missing due to the existence of multiple Wnts and their receptors. We show when Wnt secretion is abolished from motoneurons by...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Motor Neurons
Share to Muscle, Skeletal

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Neuromuscular Junction

Share to Receptors, Cholinergic

Share to Schwann Cells

Share to Synapses

Share to Wnt Proteins

Share to Wnt Signaling Pathway

Source

Open in PubMed Open full text

Identifiers

PMID: 30113308
DOI: 10.7554/eLife.34625
PMCID: PMC6128691

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Motoneuron Wnts regulate neuromuscular junction development.PMID 30113308Read ↗

Mutations in Wnt2 alter presynaptic motor neuron morphology and presynaptic protein localization at the Drosophila neuromuscular junction.Semantic proximity Read ↗

Notum coordinates synapse development via extracellular regulation of Wingless trans-synaptic signaling.Semantic proximity Read ↗

Wnt proteins contribute to neuromuscular junction formation through distinct signaling pathways.Semantic proximity Read ↗

Neuromuscular synaptogenesis in wild-type and mutant zebrafish.Semantic proximity Read ↗

Get ready to Wnt: prepatterning in neuromuscular junction formation.Semantic proximity Read ↗

Neuromuscular Development and Disease: Learning From in vitro and in vivo ModelsSemantic proximity Read ↗

Perlecan regulates bidirectional Wnt signaling at the Drosophila neuromuscular junction.Semantic proximity Read ↗

Highwire regulates presynaptic BMP signaling essential for synaptic growth.Semantic proximity Read ↗

Moving forward with the neuromuscular junctionSemantic proximity Read ↗

MAN1 Restricts BMP Signaling During Synaptic Growth in Drosophila.Semantic proximity Read ↗

Motor Neurons Decode Cholinergic Inputs via Spatially Distinct nAChR Subunits to Drive Locomotion in Drosophila larvaeSemantic proximity Read ↗

The BMP homolog Gbb provides a retrograde signal that regulates synaptic growth at the Drosophila neuromuscular junction.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.