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Article

LRP4 Is Critical for Neuromuscular Junction Maintenance

15 Oct 2014

Abstract excerpt

The neuromuscular junction (NMJ) is a synapse between motor neurons and skeletal muscle fibers, and is critical for control of muscle contraction. Its formation requires neuronal agrin that acts by binding to LRP4 to stimulate MuSK. Mutations have been identified in agrin, MuSK, and LRP4 in patients with congenital myasthenic syndrome, and patients with myasthenia gravis develop antibodies against agrin, LRP4,...

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PMID: 25319686
DOI: 10.1523/jneurosci.1733-14.2014

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Related research

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Research trail→

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LRP4 Is Critical for Neuromuscular Junction MaintenancePMID 25319686Read ↗

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The agrin/muscle‐specific kinase pathway: New targets for autoimmune and genetic disorders at the neuromuscular junctionSemantic proximity Read ↗

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The synaptic muscle‐specific kinase (MuSK) complex: New partners, new functionsSemantic proximity Read ↗

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Congenital myasthenic syndrome due to mutations in MUSK suggests that the level of MuSK phosphorylation is crucial for governing synaptic structure.Semantic proximity Read ↗

Distinct domains of MuSK mediate its abilities to induce and to associate with postsynaptic specializations.Semantic proximity Read ↗

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