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Article

A splice isoform of DNedd4, DNedd4-long, negatively regulates neuromuscular synaptogenesis and viability in Drosophila.

PloS one - 1 Jan 2011

Zhong Yunan, Shtineman-Kotler Alina, Nguyen Leo, Iliadi Konstantin G, Boulianne Gabrielle L, Rotin Daniela

Abstract excerpt

BACKGROUND: Neuromuscular (NM) synaptogenesis is a tightly regulated process. We previously showed that in flies, Drosophila Nedd4 (dNedd4/dNedd4S) is required for proper NM synaptogenesis by promoting endocytosis of commissureless from the muscle surface, a pre-requisite step for muscle innervation. DNedd4 is an E3 ubiquitin ligase comprised of a C2-WW(x3)-Hect domain architecture, which includes several splice...

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PMID: 22110599
DOI: 10.1371/journal.pone.0027007
PMCID: PMC3215714

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