Article
The basement membrane components nidogen and type XVIII collagen regulate organization of neuromuscular junctions in Caenorhabditis elegans.
The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 May 2003
Ackley Brian D, Kang Seong Hoon, Crew Jennifer R, Suh Chris, Jin Yishi, Kramer James M
Abstract excerpt
Vertebrate neuromuscular junctions (NMJs) contain specialized basal laminas enriched for proteins not found at high concentrations extrasynaptically. Alterations in NMJ basement membrane components can result in loss of NMJ structural integrity and lead to muscular dystrophies. We demonstrate here that the conserved Caenorhabditis elegans basement membrane-associated molecules nidogen/entactin (NID-1) and type...
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