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The ubiquitin ligase Nedd4 regulates craniofacial development by promoting cranial neural crest cell survival and stem-cell like properties.

Developmental biology - 15 Nov 2013

Wiszniak Sophie, Kabbara Samuela, Lumb Rachael, Scherer Michaela, Secker Genevieve, Harvey Natasha, Kumar Sharad, Schwarz Quenten

Abstract excerpt

The integration of multiple morphogenic signalling pathways and transcription factor networks is essential to mediate neural crest (NC) cell induction, delamination, survival, stem-cell properties, fate choice and differentiation. Although the transcriptional control of NC development is well documented in mammals, the role of post-transcriptional modifications, and in particular ubiquitination, has not been...

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PMID: 24080509
DOI: 10.1016/j.ydbio.2013.09.024

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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