Article
Neddylation orchestrates the complex transcriptional and posttranscriptional program that drives Schwann cell myelination.
Science advances - 12 Apr 2024
Ayuso-García Paula, Sánchez-Rueda Alejandro, Velasco-Avilés Sergio, Tamayo-Caro Miguel, Ferrer-Pinós Aroa, Huarte-Sebastian Cecilia, Alvarez Vanesa, Riobello Cristina, Jiménez-Vega Selene, Buendia Izaskun, Cañas-Martin Jorge, Fernández-Susavila Héctor, Aparicio-Rey Adrián, Esquinas-Román Eva M, Ponte Carlos Rodríguez, Guhl Romane, Laville Nicolas, Pérez-Andrés Encarni, Lavín José L, González-Lopez Monika, Cámara Nuria Macías, Aransay Ana M, Lozano Juan José, Sutherland James D, Barrio Rosa, Martinez-Chantar María Luz, Azkargorta Mikel, Elortza Félix, Soriano-Navarro Mario, Matute Carlos, Sánchez-Gómez María Victoria, Bayón-Cordero Laura, Pérez-Samartín Alberto, Bravo Susana B, Kurz Thimo, Lama-Díaz Tomas, Blanco Miguel G, Haddad Saif, Record Christopher J, van Hasselt Peter M, Reilly Mary M, Varela-Rey Marta, Woodhoo Ashwin
Abstract excerpt
Myelination is essential for neuronal function and health. In peripheral nerves, >100 causative mutations have been identified that cause Charcot-Marie-Tooth disease, a disorder that can affect myelin sheaths. Among these, a number of mutations are related to essential targets of the posttranslational modification neddylation, although how these lead to myelin defects is unclear. Here, we demonstrate that...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.