Motor endplate disease affects neuromuscular junction maturation.

Abstract excerpt

Postnatal formation of the neuromuscular synapse requires complex interactions among nerve terminal, muscle fibres and terminal Schwann cells. In motor endplate disease (med) mice, neuromuscular transmission is severely impaired without alteration of axonal conduction and a lethal paralytic phenotype occurs during the postnatal period. The med phenotype appears at a crucial stage of the neuromuscular junction...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Apoptosis
• Share to Mice
• Share to Muscle Fibers, Skeletal