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Article

Separate domains of Rev1 mediate two modes of DNA damage bypass in mammalian cells.

Molecular and cellular biology - 1 Jun 2009

Jansen Jacob G, Tsaalbi-Shtylik Anastasia, Hendriks Giel, Gali Himabindu, Hendel Ayal, Johansson Fredrik, Erixon Klaus, Livneh Zvi, Mullenders Leon H F, Haracska Lajos, de Wind Niels

Abstract excerpt

The Y family DNA polymerase Rev1 has been proposed to play a regulatory role in the replication of damaged templates. To elucidate the mechanism by which Rev1 promotes DNA damage bypass, we have analyzed the progression of replication on UV light-damaged DNA in mouse embryonic fibroblasts that contain a defined deletion in the N-terminal BRCT domain of Rev1 or that are deficient for Rev1. We provide evidence that...

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Identifiers

PMID: 19332561
DOI: 10.1128/MCB.00071-09
PMCID: PMC2682010

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Source receipt: pubmed, retrieved 7 Sept 2026.

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Separate domains of Rev1 mediate two modes of DNA damage bypass in mammalian cells.PMID 19332561Read ↗

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The vital role of polymerase ζ and REV1 in mutagenic, but not correct, DNA synthesis across benzo[a]pyrene-dG and recruitment of polymerase ζ by REV1 to replication-stalled site.Semantic proximity Read ↗

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