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Article

Temporally distinct translesion synthesis pathways for ultraviolet light-induced photoproducts in the mammalian genome.

DNA repair - 1 Jun 2012

Temviriyanukul Piya, van Hees-Stuivenberg Sandrine, Delbos Frédéric, Jacobs Heinz, de Wind Niels, Jansen Jacob G

Abstract excerpt

Replicative polymerases (Pols) arrest at damaged DNA nucleotides, which induces ubiquitination of the DNA sliding clamp PCNA (PCNA-Ub) and DNA damage signaling. PCNA-Ub is associated with the recruitment or activation of translesion synthesis (TLS) DNA polymerases of the Y family that can bypass the lesions, thereby rescuing replication and preventing replication fork collapse and consequent formation of...

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Identifiers

PMID: 22521143
DOI: 10.1016/j.dnarep.2012.03.007

Genes

PCNA
CPD

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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