Article
DNA polymerases ζ and Rev1 mediate error-prone bypass of non-B DNA structures.
Nucleic acids research - 1 Jan 2014
Northam Matthew R, Moore Elizabeth A, Mertz Tony M, Binz Sara K, Stith Carrie M, Stepchenkova Elena I, Wendt Kathern L, Burgers Peter M J, Shcherbakova Polina V
Abstract excerpt
DNA polymerase ζ (Pol ζ) and Rev1 are key players in translesion DNA synthesis. The error-prone Pol ζ can also participate in replication of undamaged DNA when the normal replisome is impaired. Here we define the nature of the replication disturbances that trigger the recruitment of error-prone polymerases in the absence of DNA damage and describe the specific roles of Rev1 and Pol ζ in handling these...
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