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Article

Opposing regulation by Rev1 of DNA polymerase zeta activity on damaged versus undamaged DNA.

Nucleic acids research - 8 Jun 2026

Bezalel-Buch Rachel, Stith Carrie, Makarova Alena V, Binz Sara K, Burgers Peter M

Abstract excerpt

The Rev1 deoxycytidyl transferase functions as a scaffold protein for DNA polymerase ζ (Pol ζ)-mediated translesion synthesis (TLS). Biochemical studies with yeast enzymes indicate that Rev1 plays a dual regulatory role in TLS, stimulating Pol ζ activity at sites of damage but inhibiting its activity on undamaged DNA. An evolutionary conserved N-terminal alpha-helical motif (M1), located 10-20 amino acids...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 42268683
DOI: 10.1093/nar/gkag568
PMCID: PMC13250573

Genes

PCNA
REV1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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Opposing regulation by Rev1 of DNA polymerase zeta activity on damaged versus undamaged DNA.PMID 42268683Read ↗

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