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Article

Vertebrate DNA damage tolerance requires the C-terminus but not BRCT or transferase domains of REV1.

Nucleic acids research - 1 Jan 2005

Ross Anna-Laura, Simpson Laura J, Sale Julian E

Abstract excerpt

REV1 is central to the DNA damage response of eukaryotes through an as yet poorly understood role in translesion synthesis. REV1 is a member of the Y-type DNA polymerase family and is capable of in vitro deoxycytidyl transferase activity opposite a range of damaged bases. However, non-catalytic roles for REV1 have been suggested by the Saccharomyces cerevisiae rev1-1 mutant, which carries a point mutation in the...

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Source

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Identifiers

PMID: 15741181
DOI: 10.1093/nar/gki279
PMCID: PMC552965

Genes

REV1
PCNA
RAD18

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Vertebrate DNA damage tolerance requires the C-terminus but not BRCT or transferase domains of REV1.PMID 15741181Read ↗

Rev1 is essential for DNA damage tolerance and non-templated immunoglobulin gene mutation in a vertebrate cell line.Semantic proximity Read ↗

The Werner's Syndrome protein collaborates with REV1 to promote replication fork progression on damaged DNA.Semantic proximity Read ↗

The critical mutagenic translesion DNA polymerase Rev1 is highly expressed during G(2)/M phase rather than S phase.Semantic proximity Read ↗

Novel role for the C terminus of Saccharomyces cerevisiae Rev1 in mediating protein-protein interactions.Semantic proximity Read ↗

A non-catalytic function of Rev1 in translesion DNA synthesis and mutagenesis is mediated by its stable interaction with Rad5.Semantic proximity Read ↗

Role of single-stranded DNA in targeting REV1 to primer termini.Semantic proximity Read ↗

Involvement of vertebrate Polkappa in translesion DNA synthesis across DNA monoalkylation damage.Semantic proximity Read ↗

Separate domains of Rev1 mediate two modes of DNA damage bypass in mammalian cells.Semantic proximity Read ↗

Post-replication repair in DT40 cells: translesion polymerases versus recombinases.Semantic proximity Read ↗

Multiple roles of vertebrate REV genes in DNA repair and recombination.Semantic proximity Read ↗

Multiple roles of Rev3, the catalytic subunit of polzeta in maintaining genome stability in vertebrates.Semantic proximity Read ↗

The DNA polymerase activity of Saccharomyces cerevisiae Rev1 is biologically significant.Semantic proximity Read ↗

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