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Article

The association study of three FYN polymorphisms with prophylactic lithium response in bipolar patients.

Human psychopharmacology - 1 Jun 2009

Szczepankiewicz Aleksandra, Skibinska Maria, Suwalska Aleksandra, Hauser Joanna, Rybakowski Janusz K

Abstract excerpt

FYN belongs to the protein kinase family that phosphorylates NMDA receptor subunits, participating in the regulation of ion transmission and BDNF/TrkB signal transduction pathway. Lithium inhibits glutamatergic transmission via NMDA receptors, exerting neuroprotective effect against excitotoxicity. The aim of this study was to find possible association of three polymorphisms of FYN gene with prophylactic lithium...

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Source

Identifiers

PMID: 19330793
DOI: 10.1002/hup.1018

Genes

FYN
BDNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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