Article
Interacting genes in lithium prophylaxis: preliminary results of an exploratory analysis on the role of DGKH and NR1D1 gene polymorphisms in 199 Sardinian bipolar patients.
Neuroscience letters - 25 Dec 2009
Manchia Mirko, Squassina Alessio, Congiu Donatella, Chillotti Caterina, Ardau Raffaella, Severino Giovanni, Del Zompo Maria
Abstract excerpt
Lithium represents the first-choice and most effective drug in the treatment of bipolar disorder (BD). While its mechanism of action is far from being totally understood, a large amount of evidence pointed to a role of second messengers mediated pathways and elements of the circadian system in modulating its mood stabilizing effect. In the present paper, we tested the possible association and interaction effect...
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