Article
Prophylactic lithium response and polymorphism of the brain-derived neurotrophic factor gene.
Pharmacopsychiatry - 1 Jul 2005
Rybakowski J K, Suwalska A, Skibinska M, Szczepankiewicz A, Leszczynska-Rodziewicz A, Permoda A, Czerski P M, Hauser J
Abstract excerpt
INTRODUCTION: Brain-derived neurotrophic factor (BDNF) has been involved in the pathogenesis of bipolar mood disorder and in the mechanism of mood-normalizing action of lithium. The aim of this study was to find a possible association between lithium prophylactic effect in bipolar patients and two polymorphisms of BDNF gene. METHODS: Eighty-eight patients (35 males, 53 females) with bipolar illness were studied....
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