Article
Mutation and association analysis of the Fyn kinase gene with alcoholism and schizophrenia.
American journal of medical genetics - 4 Dec 2000
Ishiguro H, Saito T, Shibuya H, Toru M, Arinami T
Abstract excerpt
Lack of Fyn tyrosine kinase increases alcohol sensitivity. Fyn phosphorylates a component of the NMDA receptor, which may be involved in schizophrenia. The Fyn gene is located on human chromosome 6q21, to which linkage of schizophrenia has been suggested. We hypothesized that the Fyn gene is a candidate for predisposition to alcoholism and schizophrenia, and we performed a mutation study of the 5'-flanking...
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