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Article

Association studies of the BDNF and the NTRK2 gene polymorphisms with prophylactic lithium response in bipolar patients.

Pharmacogenomics - 1 Nov 2008

Dmitrzak-Weglarz Monika, Rybakowski Janusz K, Suwalska Aleksandra, Skibinska Maria, Leszczynska-Rodziewicz Anna, Szczepankiewicz Aleksandra, Hauser Joanna

Abstract excerpt

The neuroplasticity hypothesis of bipolar disorder indicates that the BDNF/Trk signaling pathway is associated with the pathogenesis of this illness and treatment with mood stabilizers, such as lithium. This paper describes a relationship between response to lithium prophylaxis and polymorphisms of two functionally connected genes: BDNF and NTRK2, in bipolar illness. Analyses of four SNPs of the BDNF gene...

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Source

Identifiers

PMID: 19018715
DOI: 10.2217/14622416.9.11.1595

Genes

BDNF
NTRK2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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