Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Chimeric constructs between two hepatitis B virus genomes confirm transcriptional impact of core promoter mutations and reveal multiple effects of core gene mutations.

Virology - 10 May 2009

Tsai Adrienne, Kawai Shigenobu, Kwei Karen, Gewaily Dina, Hutter Alexander, Tong David R, Li Jisu, Wands Jack R, Tong Shuping

Abstract excerpt

Hepatitis B virus (HBV) clone 4B replicated much more efficiently than clone 2A of the same genotype. Introduction of its T1753C, A1762T, G1764A, and C1766T core promoter mutations into the 2A genome greatly enhanced genome replication and suppressed HBeAg expression. Here we show that these effects are mediated by transcriptional up regulation of pregenomic RNA and suppression of precore RNA. Analysis of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA, Viral
Share to Genes, Viral

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Hepatitis B virus

Share to Reassortant Viruses

Share to RNA, Viral

Share to Viral Core Proteins

Share to Virus Replication

Share to Virus Shedding

Source

Open in PubMed Open full text

Identifiers

PMID: 19327810
DOI: 10.1016/j.virol.2009.03.002
PMCID: PMC2893023

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Chimeric constructs between two hepatitis B virus genomes confirm transcriptional impact of core promoter mutations and reveal multiple effects of core gene mutations.PMID 19327810Read ↗

The Envelope Gene of Hepatitis B Virus Is Implicated in Both Differential Virion Secretion and Genome Replication Capacities between Genotype B and Genotype C Isolates.Semantic proximity Read ↗

Impact of a naturally occurring hepatitis B virus genotype D-specific core-promoter mutation on viral replication.Semantic proximity Read ↗

The A1762T/G1764A mutations enhance HBV replication by alternating viral transcriptome.Semantic proximity Read ↗

Effect of basal core promoter and pre-core mutations on hepatitis B virus replicationSemantic proximity Read ↗

Genome replication, virion secretion, and e antigen expression of naturally occurring hepatitis B virus core promoter mutants.Semantic proximity Read ↗

Hepatitis B virus genome variability and disease progression: the impact of pre-core mutants and HBV genotypes.Semantic proximity Read ↗

Naturally occurring mutations define a novel function of the hepatitis B virus core promoter in core protein expression.Semantic proximity Read ↗

Human hepatitis B virus mutants: significance of molecular changes.Semantic proximity Read ↗

In Vitro Studies Show that Sequence Variability Contributes to Marked Variation in Hepatitis B Virus Replication, Protein Expression, and Function Observed across Genotypes.Semantic proximity Read ↗

A1762T/G1764A mutations of hepatitis B virus, associated with the increased risk of hepatocellular carcinoma, reduce basal core promoter activities.Semantic proximity Read ↗

Critical role of the 36-nucleotide insertion in hepatitis B virus genotype G in core protein expression, genome replication, and virion secretion.Semantic proximity Read ↗

Full-length sequence and functional analysis of hepatitis B virus genome in a virus carrier: a case report suggesting the impact of pre-S and core promoter mutations on the progression of the disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.