Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Impact of a naturally occurring hepatitis B virus genotype D-specific core-promoter mutation on viral replication.

The Journal of general virology - 1 Feb 2026

Kanai Masatake, Shin-I Tadasu, Date Tomoko, Sakai Aiko, Mizokami Masashi, Sugiyama Masaya

Abstract excerpt

Hepatitis B virus (HBV) infects human populations worldwide. HBV strains are classified into 10 genotypes, of which the HBV genotype D (HBV/D) infection is particularly prevalent in several countries. The HBV core promoter regulates viral replication and transcription, and the naturally occurring A1762T/G1764A double mutation (CP1) in the core promoter accelerates HBV replication. Previous clinical studies showed...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cell Line
Share to DNA, Viral

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genotype

Share to Hepatitis B virus

Share to Mutation

Share to Promoter Regions, Genetic

Share to Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 41712434
DOI: 10.1099/jgv.0.002225
PMCID: PMC12919851

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 19 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Impact of a naturally occurring hepatitis B virus genotype D-specific core-promoter mutation on viral replication.PMID 41712434Read ↗

The A1762T/G1764A mutations enhance HBV replication by alternating viral transcriptome.Semantic proximity Read ↗

A1762T/G1764A mutations of hepatitis B virus, associated with the increased risk of hepatocellular carcinoma, reduce basal core promoter activities.Semantic proximity Read ↗

T1764G1766 core promoter double mutants are restricted to Hepatitis B virus strains with an A1757 and are common in genotype D.Semantic proximity Read ↗

Biological characteristics of the A1762T/G1764A mutant strain of hepatitis B virus in vivo.Semantic proximity Read ↗

Effect of basal core promoter and pre-core mutations on hepatitis B virus replicationSemantic proximity Read ↗

Chimeric constructs between two hepatitis B virus genomes confirm transcriptional impact of core promoter mutations and reveal multiple effects of core gene mutations.Semantic proximity Read ↗

Core promoter mutation of nucleotides A1762T and G1764A of hepatitis B virus increases core promoter transactivation by hepatocyte nuclear factor 1.Semantic proximity Read ↗

The core promoter of hepatitis B virus.Semantic proximity Read ↗

Novel type of hepatitis B virus mutation: replacement mutation involving a hepatocyte nuclear factor 1 binding site tandem repeat in chronic hepatitis B virus genotype E.Semantic proximity Read ↗

Genetic dissection of naturally occurring basal core promoter mutations of hepatitis B virus reveals a silent phenotype in the overlapping X gene.Semantic proximity Read ↗

Stronger enhancer II/core promoter activities of hepatitis B virus isolates of B2 subgenotype than those of C2 subgenotype.Semantic proximity Read ↗

Influence of hepatitis B virus X and core promoter mutations on hepatocellular carcinoma among patients infected with subgenotype C2.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.