Article
In Vitro Studies Show that Sequence Variability Contributes to Marked Variation in Hepatitis B Virus Replication, Protein Expression, and Function Observed across Genotypes.
Journal of virology - 15 Nov 2016
Sozzi Vitina, Walsh Renae, Littlejohn Margaret, Colledge Danni, Jackson Kathy, Warner Nadia, Yuen Lilly, Locarnini Stephen A, Revill Peter A
Abstract excerpt
The hepatitis B virus (HBV) exists as 9 major genotypes (A to I), one minor strain (designated J) and multiple subtypes. Marked differences in HBV natural history, disease progression and treatment response are exhibited by many of these genotypes and subtypes. For example, HBV genotype C is associated with later hepatitis B e antigen (HBeAg) seroconversion and high rates of liver cancer compared to other HBV...
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