Hepatitis B virus genome variability and disease progression: the impact of pre-core mutants and HBV genotypes.

doi:10.1016/s1386-6532(05)80015-0

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Article

Hepatitis B virus genome variability and disease progression: the impact of pre-core mutants and HBV genotypes.

Journal of clinical virology : the official publication of the Pan American Society for Clinical Virology - 1 Dec 2005

Buti Maria, Rodriguez-Frias Francisco, Jardi Rosendo, Esteban Rafael

Abstract excerpt

The hepatitis B virus (HBV), a member of the Hepadnaviridae family, is prone to mutations due to its asymmetric replication via reverse transcription of an RNA intermediate. The estimated mutation rate of the hepadnavirus genome is 2 x 10(4) base substitutions/site/year. This mutation rate is approximately 100 times higher than that of other DNA viruses but between 100 and 1000 times lower than that of RNA...

Topics

Animals
DNA, Viral
Disease Progression
Genetic Variation
Genome, Viral
Genotype
Hepatitis B
Hepatitis B Core Antigens
Hepatitis B virus
Humans
Promoter Regions, Genetic
Viral Core Proteins

Source

Open in PubMed

Identifiers

PMID: 16461229
DOI: 10.1016/s1386-6532(05)80015-0

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