Article
A1762T/G1764A mutations of hepatitis B virus, associated with the increased risk of hepatocellular carcinoma, reduce basal core promoter activities.
Biochemical and biophysical research communications - 3 Oct 2008
Dong Qingming, Chan Henry L Y, Liu Zheng, Chan Denise P C, Zhang Bao, Chen Yangchao, Kung Hsiang-Fu, Sung Joseph J Y, He Ming-Liang
Abstract excerpt
Hepatitis B virus (HBV) infection is a major global health problem that causes over one million deaths annually. A1762T and G1764A mutations in the basal core promoter are often present in HBV patients but seldom in asymptomatic carriers, and are highly correlated with the increased risk of HBV-associated hepatocellular carcinoma (HCC). In this study, for the first time, we show that the basal core promoter...
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