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Article

Effect of basal core promoter and pre-core mutations on hepatitis B virus replication

14 Mar 2008

Abstract excerpt

There are two hypotheses explaining a fulminant outcome after hepatitis B virus (HBV) infection, both of which may be applicable at the same time: (i) basal core promoter (BCP) mutations increase viral replication, allowing rapid spread of the virus through the liver, and (ii) pre-core (pre-C) mutations abrogating hepatitis B e antigen (HBeAg) synthesis remove its tolerogenic effect, leading to a vigorous immune...

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PMID: 18343830
DOI: 10.1099/vir.0.83468-0

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