Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Naturally occurring mutations define a novel function of the hepatitis B virus core promoter in core protein expression.

Journal of virology - 1 Aug 1998

Baumert T F, Marrone A, Vergalla J, Liang T J

Abstract excerpt

Functional analysis of naturally occurring hepatitis B virus (HBV) mutations is crucial in understanding their impact on disease. We have recently identified two mutations in the HBV core promoter of an HBV strain associated with fulminant hepatitis leading to highly (15-fold) enhanced replication as a result of increased viral encapsidation of pregenomic RNA into the core particles (T. F. Baumert et al., J....

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Genes, Viral
Share to Hepatitis B virus
Share to Mutagenesis

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Mutation

Share to Open Reading Frames

Share to Promoter Regions, Genetic

Share to Tumor Cells, Cultured

Share to Virus Replication

Source

Open in PubMed Open full text

Identifiers

PMID: 9658127
DOI: 10.1128/JVI.72.8.6785-6795.1998
PMCID: PMC109887

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Naturally occurring mutations define a novel function of the hepatitis B virus core promoter in core protein expression.PMID 9658127Read ↗

Effect of basal core promoter and pre-core mutations on hepatitis B virus replicationSemantic proximity Read ↗

Core protein mutations are key determinants of hepatitis B virus replication during the hepatitis B e antigen-negative stage.Semantic proximity Read ↗

Genome replication, virion secretion, and e antigen expression of naturally occurring hepatitis B virus core promoter mutants.Semantic proximity Read ↗

Effects of a naturally occurring mutation in the hepatitis B virus basal core promoter on precore gene expression and viral replicationSemantic proximity Read ↗

Chimeric constructs between two hepatitis B virus genomes confirm transcriptional impact of core promoter mutations and reveal multiple effects of core gene mutations.Semantic proximity Read ↗

The core promoter of hepatitis B virus.Semantic proximity Read ↗

Genetic dissection of naturally occurring basal core promoter mutations of hepatitis B virus reveals a silent phenotype in the overlapping X gene.Semantic proximity Read ↗

Transcriptional regulation of precore and pregenomic RNAs of hepatitis B virusSemantic proximity Read ↗

Functional characterization of naturally occurring variants of human hepatitis B virus containing the core internal deletion mutation.Semantic proximity Read ↗

Mutations in the core promoter region of hepatitis B virus in patients with chronic hepatitis B.Semantic proximity Read ↗

Hepatitis B Virus e Antigen VariantsSemantic proximity Read ↗

Full-length sequence and functional analysis of hepatitis B virus genome in a virus carrier: a case report suggesting the impact of pre-S and core promoter mutations on the progression of the disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.