Article
Naturally occurring mutations define a novel function of the hepatitis B virus core promoter in core protein expression.
Journal of virology - 1 Aug 1998
Baumert T F, Marrone A, Vergalla J, Liang T J
Abstract excerpt
Functional analysis of naturally occurring hepatitis B virus (HBV) mutations is crucial in understanding their impact on disease. We have recently identified two mutations in the HBV core promoter of an HBV strain associated with fulminant hepatitis leading to highly (15-fold) enhanced replicatio...
Topics
- Gene Expression Regulation, Viral
- Genes, Viral
- Hepatitis B Core Antigens
- Hepatitis B virus
- Humans
- Mutagenesis
- Mutation
- Open Reading Frames
- Promoter Regions, Genetic
- Protein Precursors
- RNA-Directed DNA Polymerase
- Tumor Cells, Cultured
- Virus Replication