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Article

Core protein mutations are key determinants of hepatitis B virus replication during the hepatitis B e antigen-negative stage.

The Journal of general virology - 1 Sept 2026

Flichman Diego, García María Cecilia, Granchetti Hugo Norberto, Campos Rodolfo, Elizalde María Mercedes

Abstract excerpt

The natural history of chronic hepatitis B virus (HBV) infection comprises distinct stages resulting from virus-host interactions. A late and pivotal event in this process is hepatitis B e antigen (HBeAg) seroconversion, marked by the abrogation of HBeAg expression, a significant reduction in viral load and the accumulation of mutations throughout the genome, particularly within the Core region. While HBeAg loss...

Read the complete abstract on PubMed

Topics

Hepatitis B virus
Virus Replication
Humans
Hepatitis B e Antigens
Mutation
Viral Core Proteins

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

DNA, Viral

Hepatitis B, Chronic

Viral Load

Genome, Viral

Source

Open in PubMed Open full text

Identifiers

PMID: 42696345
DOI: 10.1099/jgv.0.002303
PMCID: PMC13544899

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 24 Oct 2026.

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