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Article

Genome replication, virion secretion, and e antigen expression of naturally occurring hepatitis B virus core promoter mutants.

Journal of virology - 1 Jun 2003

Parekh Sameer, Zoulim Fabien, Ahn Sang Hoon, Tsai Adrienne, Li Jisu, Kawai Shigenobu, Khan Nasser, Trépo Christian, Wands Jack, Tong Shuping

Abstract excerpt

The core promoter mutants of hepatitis B virus (HBV) emerge as the dominant viral population at the late HBeAg and the anti-HBe stages of HBV infection, with the A1762T/G1764A substitutions as the hotspot mutations. The double core promoter mutations were found by many investigators to moderately enhance viral genome replication and reduce hepatitis B e antigen (HBeAg) expression. A much higher replication...

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Share to Gene Expression Regulation, Viral
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 12767980
DOI: 10.1128/jvi.77.12.6601-6612.2003
PMCID: PMC156182

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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