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Article

The A1762T/G1764A mutations enhance HBV replication by alternating viral transcriptome.

Journal of medical virology - 1 Oct 2023

Yang Danli, Zou Jun, Guan Guiwen, Feng Xiaoyu, Zhang Ting, Li Guixin, Liu Hui, Zheng Huiling, Xi Jingyuan, Yu Guangxin, Dai Lizhong, Lu Fengmin, Chen Xiangmei

Abstract excerpt

The A1762T/G1764A mutations, one of the most common mutations in the hepatitis B virus basal core promoter, are associated with the progression of chronic HBV infection. However, effects of these mutations on HBV replication remains controversial. This study aimed to systematically investigate the effect of the mutations on HBV replication and its underlying mechanisms. Using the prcccDNA/pCMV-Cre recombinant...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 37772469
DOI: 10.1002/jmv.29129

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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