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Article

DNA hypermethylation in Drosophila melanogaster causes irregular chromosome condensation and dysregulation of epigenetic histone modifications.

Molecular and cellular biology - 1 Apr 2003

Weissmann Frank, Muyrers-Chen Inhua, Musch Tanja, Stach Dirk, Wiessler Manfred, Paro Renato, Lyko Frank

Abstract excerpt

The level of genomic DNA methylation plays an important role in development and disease. In order to establish an experimental system for the functional analysis of genome-wide hypermethylation, we overexpressed the mouse de novo methyltransferase Dnmt3a in Drosophila melanogaster. These flies showed severe developmental defects that could be linked to reduced rates of cell cycle progression and irregular...

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Identifiers

PMID: 12640138
DOI: 10.1128/MCB.23.7.2577-2586.2003
PMCID: PMC150732

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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