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Article

Position-effect variegation, heterochromatin formation, and gene silencing in Drosophila.

Cold Spring Harbor perspectives in biology - 1 Aug 2013

Elgin Sarah C R, Reuter Gunter

Abstract excerpt

Position-effect variegation (PEV) results when a gene normally in euchromatin is juxtaposed with heterochromatin by rearrangement or transposition. When heterochromatin packaging spreads across the heterochromatin/euchromatin border, it causes transcriptional silencing in a stochastic pattern. PEV is intensely studied in Drosophila using the white gene. Screens for dominant mutations that suppress or enhance...

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Identifiers

PMID: 23906716
DOI: 10.1101/cshperspect.a017780
PMCID: PMC3721279

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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