Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Expression of functional D299G.T399I polymorphic variant of TLR4 depends more on coexpression of MD-2 than does wild-type TLR4.

Journal of immunology (Baltimore, Md. : 1950) - 15 Apr 2010

Prohinar Polonca, Rallabhandi Prasad, Weiss Jerrold P, Gioannini Theresa L

Abstract excerpt

Two missense variants (D299G and T399I) of TLR4 are cosegregated in individuals of European descent and, in a number of test systems, result in reduced responsiveness to endotoxin. How these changes within the ectodomain (ecd) of TLR4 affect TLR4 function is unclear. For both wild-type and D299G.T399I TLR4, we used endotoxinCD14 and endotoxinMD-2 complexes of high specific radioactivity to measure: 1) interaction...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Substitution
Share to Dose-Response Relationship, Immunologic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Endotoxins

Share to Lipopolysaccharides

Share to Mutation, Missense

Share to Protein Binding

Share to Protein Structure, Tertiary

Share to Toll-Like Receptor 4

Source

Open in PubMed Open full text

Identifiers

PMID: 20212095
DOI: 10.4049/jimmunol.0903142
PMCID: PMC2881700

Genes

TLR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Expression of functional D299G.T399I polymorphic variant of TLR4 depends more on coexpression of MD-2 than does wild-type TLR4.PMID 20212095Read ↗

Molecular genetic analysis of an endotoxin nonresponder mutant cell line: a point mutation in a conserved region of MD-2 abolishes endotoxin-induced signaling.Semantic proximity Read ↗

A mouse model of human TLR4 D299G/T399I SNPs reveals mechanisms of altered LPS and pathogen responses.Semantic proximity Read ↗

Structural analyses of human Toll-like receptor 4 polymorphisms D299G and T399I.Semantic proximity Read ↗

Cutting edge: cells that carry A null allele for toll-like receptor 2 are capable of responding to endotoxin.Semantic proximity Read ↗

Characterization and investigation of single nucleotide polymorphisms and a novel TLR2 mutation in the human TLR2 gene.Semantic proximity Read ↗

TLR4 mutations are associated with endotoxin hyporesponsiveness in humans.Semantic proximity Read ↗

Essential roles of hydrophobic residues in both MD-2 and toll-like receptor 4 in activation by endotoxin.Semantic proximity Read ↗

The role of TLR4 in endotoxin responsiveness in humans.Semantic proximity Read ↗

Analysis of TLR4 polymorphic variants: new insights into TLR4/MD-2/CD14 stoichiometry, structure, and signaling.Semantic proximity Read ↗

The TLR4 D299G and T399I SNPs are constitutively active to up-regulate expression of Trif-dependent genes.Semantic proximity Read ↗

Endotoxin exposure, CD14 and wheeze among farmers: a gene--environment interaction.Semantic proximity Read ↗

Polymorphisms of TLR4: rapid genotyping and reduced response to lipopolysaccharide of TLR4 mutant alleles.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.