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Article

MD-2 mediates the ability of tetra-acylated and penta-acylated lipopolysaccharides to antagonize Escherichia coli lipopolysaccharide at the TLR4 signaling complex.

Journal of immunology (Baltimore, Md. : 1950) - 1 Oct 2005

Coats Stephen R, Pham Thu-Thao T, Bainbridge Brian W, Reife Robert A, Darveau Richard P

Abstract excerpt

We have demonstrated previously that tetra-acylated LPS derived from the oral bacterium, Porphyromonas gingivalis, and penta-acylated msbB LPS derived from a mutant strain of Escherichia coli can antagonize the ability of canonical hexa-acylated E. coli LPS to signal through the TLR4 signaling complex in human endothelial cells. Activation of the TLR4 signaling complex requires the coordinated function of LPS...

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Source

Identifiers

PMID: 16177092
DOI: 10.4049/jimmunol.175.7.4490

Genes

TLR4
LBP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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